ROS and cell migration
Collective and planktonic cell migration are important for epithelial cell homeostasis, recovery from injury, infection or inflammation. Although a great deal is known about some of the structural and mechanical forces and proteins involved in this process, the mechanisms of how ROS and specifically hydrogen peroxide signaling alter migration are less
NOX1 and cell migration
NOX1 is important for directional migration in cells
COS7 cells expressing wild type or mutant NOX1 following a scratch wound

Cells expressing functional NOX1 have increased and more well defined focal adhesions

Loss of NOX1 function does not alter the speed /extent of planktonic cellular migration but is important for directing the cells toward a chemokine gradient.