Cohen JL, Duyzend M, Adelson SM, Yeo J, Fleming M, Ganetzky R, Hale R, Mitchell DM, Morton SU, Reimers R, Roberts A, Strong A, Tan W, Thiagarajah JR, Walker MA, Green RC, Gold NB. Advancing precision care in pregnancy through a treatable fetal findings list. Am J Hum Genet. 2025 Apr 3:S0002-9297(25)00110-7. PMID: 40209713.

Gaibee Z, Warner N, Bugda Gwilt K, Li W, Guan R, Yourshaw M, Whittaker Hawkins R, Zorbas C, St-Germain J, Tabatabaie M, Mao S, Pinsk V, Yerushalmi B, Wang Lk, Nelson SF, Wozniak L, Shouval DS, Matar M, Assa A, Frost N, Jimenez L, Acra S, Walters T, Mouat S, Li M, Lafontaine DLJ, Tyska M, Raught B, Avitzur Y, Lencer WI, Goldenring JR, Martin MG, Thiagarajah JR, Muise AM. The Genetic Architecture of Congenital Diarrhea and Enteropathy. N Engl J Med. 2025 Apr 3;392(13):1297-1309. PMID: 40174224.

Thiagarajah JR. Stretch and Flex: Mechanosensing and Stem Cells. Gastroenterology. 2025 Mar 5:S0016-5085(25)00481-0. PMID: 40054746. 

Hsu AY, Huang Q, Pi X, Fu J, Raghunathan K, Ghimire L, Balasubramanian A, Xie X, Yu H, Loison F, Haridas V, Zha J, Liu F, Park SY, Bagale K, Ren Q, Fan Y, Zheng Y, Cancelas JA, Chai L, Stowell SR, Chen K, Xu R, Wang X, Xu Y, Zhang L, Cheng T, Ma F, Thiagarajah JR, Wu H, Feng S, Luo HR. Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution. Cell. 2025 Mar 20;188(6):1623-1641.e26. PMID: 39938514.

French CE, Andrews NC, Beggs AH, Boone PM, Brownstein CA, Chopra M, Chou J, Chung WK, D'Gama AM, Doan RN, Ebrahimi-Fakhari D, Goldstein RD, Irons M, Jacobsen C, Kenna M, Lee T, Madden JA, Majmundar AJ, Mann N, Morton SU, Poduri A, Randolph AG, Roberts AE, Roberts S, Sampson MG, Shao DD, Shao W, Sharma A, Shearer E, Shimamura A, Snapper SB, Srivastava S, Thiagarajah JR, Whitman MC, Wojcik MH, Rockowitz S, Sliz P. Hospital-wide access to genomic data advanced pediatric rare disease research and clinical outcomes. NPJ Genom Med. 2024 Dec2;9(1):60. PMID: 39622807.

Jena KK, Mambu J, Boehmer D, Sposito B, Millet V, de Sousa Casal J, Muendlein HI, Spreafico R, Fenouil R, Spinelli L, Wurbel S, Riquier C, Galland F, Naquet P, Chasson L, Elkins M, Mitsialis V, Ketelut-Carneiro N, Bugda Gwilt K, Thiagarajah JR, Ruan HB, Lin Z, Lien E, Shao F, Chou J, Poltorak A, Ordovas-Montanes J, Fitzgerald KA, Snapper SB, Broggi A, Zanoni I. Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair. Cell. 2024 Dec 26;187(26):7533-7550.e23. PMID: 39500322.

Bugda Gwilt K, Thiagarajah JR. Overcoming problematic growth phenotypes in organoids from patients with monogenic GI disease. PLoS One. 2024 Nov 4;19(11):e0309072. PMID: 39495812.

La J, Raghunathan K, Silvester JA, Thiagarajah JR. ViCE: An automated and quantitative program to assess intestinal tissue morphology. J Pathol Inform. 2024 Sep 13;15:100397. PMID: 39435455.

Thiagarajah JR. A MERFISHing Expedition for Colitis. Gastroenterology. 2024 Nov;167(6):1239-1240. PMID: 39102963.

Avitzur Y, Jimenez L, Martincevic I, Acra S, Courtney-Martin G, Gray M, Hope K, Muise A, Prieto Jimenez PM, Taylor N, Thiagarajah JR, Martin MG; PediCODE Consortium. Diet management in congenital diarrheas and enteropathies - general concepts and disease-specific approach, a narrative review. AM J Clin Nutr. 2024 Jul;120(1):17-33. PMID: 38734141.

O'Connell AE, Raveenthiraraj S, Oliveira LFS, Adegboye C, Dasuri VS, Qi W, Khetani RS, Singh A, Sundaram N, Lin J, Nandivada P, Rincon-Cruz L, Goldsmith JD, Thiagarajah JR, Carlone DL, Turner JR, Agrawal PB, Helmrath M, Breault DT. WNT2B Deficiency Causes Enhanced Susceptibility to Colitis Due to Increased Inflammatory Cytokine Production. Cell Mol Gastroenterol Hepatol. 2024;18(2):101349. PMID: 38697357.

Kaji I, Thiagarajah JR, Goldenring JR. Modeling the cell biology of monogenetic intestinal epithelial disorders. J Cell Biol. 2024 Jul 1;233(7):e202310118. PMCID: PMC11058565.

Thiagarajah JR. Holding Back the Tide: Interferon-gamma to the Rescue. Gastroenterology. 2024 Jun;166(6):1191-1192. PMID: 38340870.

Thiagarajah JR. Intermittent Feasting: Dampening Our Gut Immune Spirits. Gastroenterology. 2024 Jan;166(1):212. PMID: 37741420. 

Kalashyan M, Raghunathan K, Oller H, Bayer MT, Jimenez L, Roland JT, Kolobova E, Hagen SJ, Goldsmith JD, Shub MD, Goldenring JR, Kaji I, Thiagarajah JR. Patient-derived enteroids provide a platform for the development of therapeutic approaches in microvillus inclusion disease. J Clin Invest. 2023 Oct 16;133(20):e169234. PMID: 37643022. 

Zilbauer M, James KR, Kaur M, Pott S, Li Z, Burger A, Thiagarajah JR, Burclaff J, Jahnsen FL, Perrone F, Ross AD, Matteoli G, Stakenborg N, Sujino T, Moor A, Bartolome-Casado R, Bækkevold ES, Zhou R, Xie B, Lau KS, Din S, Magness ST, Yao Q, Beyaz S, Arends M, Denadai-Souza A, Coburn LA, Gaublomme JT, Baldock R, Papatheodorou I, Ordovas-Montanes J, Boeckxstaens G, Hupalowska A, Teichmann SA, Regev A, Xavier RJ, Simmons A, Snyder MP, Wilson KT; Gut Cell Atlas Consortium; Human Cell Atlas Gut Biological Network Consortium. A Roadmap for the Human Gut Cell Atlas. Nat Rev Gastroenterol Hepatol. 2023 Sep;20(9):597-614. PMID: 37258747. 

Gold NB, Adelson SM, Shah N, Williams S, Bick SL, Zoltick ES, Gold JI, Strong A, Ganetzky R, Roberts AE, Walker M, Holtz AM, Sankaran VG, Delmonte O, Tan W, Holm IA, Thiagarajah JR, Kamihara J, Comander J, Place E, Wiggs J, Green RC. Perspectives of Rare Disease Experts on Newborn Genome Sequencing. JAMA Netw Open. 2023 May 1;6(5):e2312231. PMID: 37155167. 

Babcock SJ, Flores-Marin D, Thiagarajah JR. The genetics of monogenic intestinal epithelial disorders. Hum Genet. 2023 May;142(5):613-654. PMID: 36422736.

O'Connell AE, Raveenthiraraj S, Adegboye C, Qi W, Khetani RS, Singh A, Sundaram N, Emeonye C, Lin J, Goldsmith JD, Thiagarajah JR, Carlone DL, Turner JR, Agrawal PB, Helmrath M, Breault DT. WNT2B Deficiency Causes Increased Susceptibility to Colitis in Mice and Impairs Intestinal Epithelial Development in Humans. bioRxiv [Preprint]. 2023 Apr 22:2023.04.21.537894. PMID: 37131772.

Thiagarajah JR. The Immune Ghosts of Pandemics Past. Gastroenterology. 2023 Apr;164(4):696. PMID: 36608717. 

Devant P, Boršić E, Ngwa EM, Xiao H, Chouchani ET, Thiagarajah JR, Hafner-Bratkovič I, Evavold CL, Kagan JC. Gasdermin D pore-forming activity is redox-sensitive. Cell Rep. 2023 Jan 31;42(1):112008. PMID: 36662620. 

Kalashyan M, Raghunathan K, Oller H, Theres MB, Jimenez L, Roland JT, Kolobova E, Hagen SJ, Goldsmith JD, Shub MD, Goldenring JR, Kaji I, Thiagarajah JR. Therapy Development for Microvillus Inclusion Disease using Patient-derived Enteroids. bioRxiv [Preprint]. 2023 Jan 29:2023.01.28.526036. Update in: J Clin Invest. 2023 Aug 29. PMID: 36747680. 

2022  

Yang D, Jacobson A, Meerschaert KA, Sifakis JJ, Wu M, Chen X, Yang T, Zhou Y, Anekal PV, Rucker RA, Sharma D, Sontheimer-Phelps A, Wu GS, Deng L, Anderson MD, Choi S, Neel D, Lee N, Kasper DL, Jabri B, Huh JR, Johansson M, Thiagarajah JR, Riesenfeld SJ, Chiu IM. Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection. Cell. 2022 Oct 27;185(22):4190-4205.e25. PMID: 36243004.

Thiagarajah JR. Disrupting Polarized Trafficking in Intestinal Epithelial Cells: Insights From a Novel Congenital Enteropathy Gene. Gastroenterology. 2022 Sep;163(3):777. PMID: 35728684. 

Grey MJ, De Luca H, W ard DV, Kreulen IA, Bugda Gwilt K, Foley SE, Thiagarajah JR, McCormick BA, Turner JR, Lencer WI. The epithelial-specific ER stress sensor ERN2/IRE1β enables host-microbiota crosstalk to affect colon goblet cell development. J Clin Invest. 2022 Sep 1;132(17):e153519. PMID: 35727638. 

Budga Gwilt K, Thiagarajah JR. Membrane Lipids in Epithelial Polarity: Sorting out the PIPs. Front Cell Dev Biol. 2022 May 31;10:893960. PMID:35712665.

2021 

Otuya DO, Gavgiotaki E, Carlson CJ, Shi SQ, Lee AJ, Krall AA, Chung A, Grant CG, Bhat NM, Choy P, Giddings SL, Gardecki JA, Thiagarajah JR, Rowe SM, Tearney GJ. Minimally Invasive Image-Guided Gut Transport Function Measurement Probe. Front Phys. 2021 Sep;9:735645. PMID: 36382063.

Evavold CL, Hafner-Bratkovic I, Devant P, D'Andrea JM, Ngwa EM, Borsic E, Doench JG, LaFleur MW, Sharpe AH, Thiagarajah JR, Kagan JC. Control of gasdermin D oligomerization and pyroptosis by the Raguator-Rag-mTORC1 pathway. Cell. 2021 Aug 19;184(17):4495-4511.e19. PMID: 34289345.

Zhang YJ, Jimenez L, Azova S, Kremen J, Chan YM, Elhusseiny AM, Saeed H, Goldsmith J, Al-Ibraheemi A, O'Connell AR, Kovbasnjuk O, Rodan L, Agrawal PB, Thiagarajah JR. Novel variants in the stem cell niche factor WNT2B define the disease phenotype as a congenital enteropathy with ocular dysgenesis. Eur J Hum Genet. 2021 Jun;29(6):998-1007. PMID: 33526876.

Pinkard H, Stuurman N, Ivanov IE, Anthony NM, Ouyang W, Li, B, Yang B, Tsuchida MA, Chhun B, Zhang G,  Mei R, Anderson M, Shepherd DP, Hunt-Isaak I, Dunn RL, Jahr W, Kato S, Royer LA, Thiagarajah JR, Eliceiri KW, Lundberg E, Mehta SB, Waller L. Pycro-Manager:open-source software for customized and reproducible microscope control. Nat Methods 2021 Mar; 18:226-228. PMID: 33674797.

Zhang YJ, Jimenez L, Azova S, Kremen J, Chan Y-M, Elhusseiny AM, Saeed H, Goldsmith J, Al-Ibraheemi A, Connell AEO, Kovbasnjuk O, Rodan L, Agrawal PB, Thiagarajah JR. Novel variants in the stem cell niche factor WNT2B define the disease phenotype as a congenital enteropathy with ocular dysgenesis. Eur J Hum Genet EJHG. 2021 Feb 1; PMID: 33526876.

Chang D, Whiteley AT, Bugda Gwilt K, Lencer WI, Mekalanos JJ, Thiagarajah JR. Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27502–27508. PMID: 33087577

Khoshnevisan R, Anderson M, Babcock S, Anderson S, Illig D, Marquardt B, Sherkat R, Schröder K, Moll F, Hollizeck S, Rohlfs M, Walz C, Adibi P, Rezaei A, Andalib A, Koletzko S, Muise AM, Snapper SB, Klein C, Thiagarajah JR, Kotlarz D. NOX1 Regulates Collective and Planktonic Cell Migration: Insights From Patients With Pediatric-Onset IBD and NOX1 Deficiency. Inflamm Bowel Dis. 2020 Jul 17;26(8):1166–1176. PMCID: PMC7365810.

Grey MJ, Cloots E, Simpson MS, LeDuc N, Serebrenik YV, De Luca H, De Sutter D, Luong P, Thiagarajah JR, Paton AW, Paton JC, Seeliger MA, Eyckerman S, Janssens S, Lencer WI. IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress. J Cell Biol. 2020 Feb 3;219(2). PMCID: PMC7041686.

Luong P, Li Q, Chen P-F, Wrighton PJ, Chang D, Dwyer S, Bayer M-T, Snapper SB, Hansen SH, Thiagarajah JR, Goessling W, Lencer WI. A quantitative single-cell assay for retrograde membrane traffic enables rapid detection of defects in cellular organization. Mol Biol Cell. 2020 19;31(7):511–519. PMCID: PMC7202069.

Jardine S, Anderson S, Babcock S, Leung G, Pan J, Dhingani N, Warner N, Guo C, Siddiqui I, Kotlarz D, Dowling JJ, Melnyk RA, Snapper SB, Klein C, Thiagarajah JR, Muise AM. Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Disease Caused by TTC7A Deficiency. Gastroenterology. 2020 Mar;158(4):1000–1015. PMCID: PMC7062591.

2019

Duan T, Cil O, Thiagarajah JR, Verkman AS. Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea. JCI Insight. 2019 Feb 21;4(4). PMCID: PMC6478423.

2018

Luong P, Hedl M, Yan J, Zuo T, Fu T-M, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI. INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. eLife. 2018 Oct 25;7. PMCID: PMC6226287.

Anez-Bustillos L, Dao DT, Potemkin AK, Perez-Atayde AR, Raphael BP, Carey AN, Kamin DS, Thiagarajah JR, Crowley M, Gura KM, Puder M. An Intravenous Fish Oil-Based Lipid Emulsion Successfully Treats Intractable Pruritus and Cholestasis in a Patient with Microvillous Inclusion Disease. Hepatol Baltim Md. 2019 Mar;69(3):1353–1356. PMCID: PMC6507398.

O’Connell AE, Zhou F, Shah MS, Murphy Q, Rickner H, Kelsen J, Boyle J, Doyle JJ, Gangwani B, Thiagarajah JR, Kamin DS, Goldsmith JD, Richmond C, Breault DT, Agrawal PB. Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. Am J Hum Genet. 2018 Jun 4; PMID: 29909964.

Thiagarajah JR, Kamin DS, Acra S, Goldsmith JD, Roland JT, Lencer WI, Muise AM, Goldenring JR, Avitzur Y, Martín MG, PediCODE Consortium. Advances in Evaluation of Chronic Diarrhea in Infants. Gastroenterology. 2018 Jun;154(8):2045-2059. e6. PMCID: PMC6044208.